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Research briefings (2022 winter edition)

1. Ying Qu, associate professor from Department of Hematology and Institute of and Professor Qian Zhiyong from State Key Laboratory of Biotherapy recently published a research article titled “Cancer-Cell-Biomimetic Nanoparticles for Targeted Therapy of Multiple Myeloma Based on Bone Marrow Homing” in Advanced Materials (IF: 32.086). By simulating the bone marrow homing characteristics of myeloma, the study prepared a myeloma cell biomimetic nano-system, which solved the problem of insufficient drug concentration in the bone marrow in the treatment of multiple myeloma, and laid a good foundation for the treatment of hematologic malignancies with nanomedicine.


2. Recently, the team of Associate Professor Luo Ting from the Breast Disease Center and the team of Associate Professor Luo Min from the State Key Laboratory of Biotherapy published the review paper titled “The Hippo signaling pathway and its implications in human health and diseases” in Signal Transformation and Targeted Therapy (IF: 38.104), which systematically expounded the physiological and pathological regulation functions of Hippo, an important signal pathway involved in tumor occurrence and development, and its upstream and downstream regulatory signals.


3. Professor Li Lin’s team from the Department of Nuclear Medicine published six case analysis articles in Clinical Nuclear Medicine, which profoundly analyzed the imaging manifestations, clinical features and pathological diagnosis of six different diseases, and systematically demonstrated FDG PET/CT’s diagnosis of differential tumors and lesions and its value.

(1). A Stromal Tumor Presenting as a Pseudoaneurysmal Dilation of the Small Bowel Mimicking a Lymphoma on FDG PET/CT

(2). Solitary Chest Wall Tuberculosis Mimicking a Malignancy Demonstrated on FDG PET/CT

  (3). FDG PET/CT Image of a Solitary Rib Hamartoma


(4). Solitary Lymph Node Metastasis from a Malignant Peripheral Nerve Sheath Tumor of the Thoracic Vertebra Revealed on FDG PET/CT


(5). FDG PET/CT Image of Soft Tissue Aneurysmal Bone Cyst


(6). Angiofibroma of Soft Tissue on MRI and FDG PET/CT Image


4. Recently, Associate Professor Luo Han from the Department of Thyroid Surgery and Professor Xu Heng from the Biotherapy Research Center jointly published a research paper titled “Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment” in Nature Communications (IF: 17.694). On the basis of integrating the single cell transcriptome data of ten types of solid tumors, the plasticity and heterogeneity of tumor-related fibroblasts in the progression of pan-tumor species were explored and revealed from the perspective of single cell resolution.


5. Recently, Associate Professor Lei Jianyong and Professor Li Zhihui from the Department of Thyroid Surgery published a review article titled “The updated role of exosomal proteins in the diagnosis, prognosis, and treatment of cancer” in Experimental & Molecular Medicine (IF: 12.172), which summarized the influence of exosomal proteins on tumor occurrence and development, emphasized the role of exosomal proteins in the diagnosis and prognosis of various cancers, and expounded the potential application of exosomal proteins in cancer treatment.


6. Lately, researchers from Department of Thyroid Surgery of WCH and Karolinska Institute, Sweden, published a research paper titled “Pancreatic tumor eradication via selective Pin1 inhibition in cancer-associated fibroblasts and T lymphocytes engagement” in Nature Communications (IF=17. 694). In this research, a prolyl isomerase PIN1 inhibitor delivery system based on CAFs targeting antibody and DNA barcode bundle gel system was developed. The system introduced CD8 + T cells into the tumor with the help of CD8 + T cell specific aptamer to eradicate the pancreatic tumor cells in the mouse pancreatic in situ model. Current study highlighted the possibility of treatment on pancreatic cancer by reshaping the tumor microenvironment.


7. Recently, the team of Professor Hu Bing from the Department of Gastroenterology published a research article titled “Artificial intelligence for detecting and delineating a small flat-type early esophageal squamous cell carcinoma under multimodal imaging” in Endoscope (IF: 10.437). The article disclosed the whole process that the team used the self-developed AI-aided diagnosis system to discover a case of early esophageal cancer with the smallest area reported in international literature, and successfully implemented the endoscopic minimally invasive treatment.


8. Recently, Professor Yang Shengyong’s team from the Biotherapy Research Center published a paper in Nature Communications, a sub-journal of Nature. The article titled “Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor” revealed the research process of discovering small molecule inhibitors of RIPK1 based on their proposed generative deep learning (GDL) model. This study manifested the ability of the GDL model in generating molecules with new scaffolds, thus highlighting the great potential of deep learning in drug discovery.


9. Recently, Professor Sun Xin from the Center for Clinical Epidemiology and Evidence-based Medicine/IDEAL China Center and Professor Wen Tianfu from the Department of Liver Surgery jointly published a research paper on the transformation of advanced liver cancer titled “Programmed cell death protein 1 and tyrosine kinase inhibition plus transcatheter arterial chemoembolization of advanced hepatocellular carcinoma” in British Journal of Surgery (IF: 11.782) based on the IDEAL methodology framework. By analyzing the diagnosis and treatment of liver cancer patients, this study tested the preliminary safety and effectiveness of renvatinib combined with transcatheter arterial chemoembolization and PD-1 (LEN-TAP), the world’s first triple transformation scheme (the Huaxi Scheme).


10. In November 2022, Professor He Jinhan’s team from the Institute of Metabolic Diseases and Drug Therapy published a research paper titled “MANF in POMC neurons promotes brown adipose tissue thermogenesis and protects against diet-induced obesity” in Diabetes, a famous international journal in the field of diabetes. It was the first time to reveal the important regulation of midbrain astrocyte-derived neurotrophic factor MANF in hypothalamic POMC neurons on energy balance, and to clarify the central and peripheral molecular mechanisms of its regulation of energy metabolism through hypothalamic-adipose tissue crosstalk. This study further confirmed that MANF is a potential therapeutic target for obesity and related metabolic disorders, thus providing a mechanism basis for its role.


11. In July 2022, Gong Meng, associate professor from the Institute of Disease Systematic Genetics/the Frontier Science Center of Disease Molecular Network/the Proteomics-Metabonomics Platform, cooperated with Li Tao, professor from the Anesthesia Surgery Center/Mitochondrial and Metabolic Research Lab to publish in Biomaterials (IF: 15.304) an article titled “Integrated metabolomics revealed the fibromyalgia-alleviation effect of Mo2C nanozyme through regulated homeostasis of oxidative stress and energy metabolism.” It was found for the first time that Mo2C nanoenzyme has therapeutic effect on fibromyalgia induced by reserpine, and the molecular mechanism of this nanoenzyme in relieving fibromyalgia by scavenging reactive oxygen species and regulating energy metabolism are revealed with the help of comprehensive metabonomics technology for the first time. This study believed that Mo2C nanoenzyme has the potential to be used as a therapeutic drug for fibromyalgia, providing a new idea for clinical treatment of fibromyalgia.