研究方向：肿瘤细胞与分子生物学，包括癌基因功能、肿瘤细胞信号转导等，在此基础上探索肿瘤治疗方案。

     科室简介：本研究室在蒋扬富教授带领下主要开展肿瘤细胞与分子生物学研究，以乳腺癌、肝癌等实体瘤为研究对象，开展生长因子受体信号传导、肿瘤细胞应激反应、肿瘤转移及肿瘤化学预防等几个方向的研究。这些研究有助于探索癌基因在肿瘤发生、发展中的作用机理及肿瘤预防或靶向治疗策略。研究室先后承担了国家重大科技专项（1项）、国家自然科学基金项目（7项）、教育部博士点基金项目（1项）、教育部新世纪优秀人才支持计划（1项）、四川省青年科技基金项目（2项）等。在Cell Research 、Journal of Pathology、Medicinal Research Reviews、British Journal of Pharmacology、Journal of Hematology & Oncology、JBC、Breast Cancer Research、Cell Death & Disease等刊物发表多篇论文。本研究室现有博士师导师1名, 实验技师1名。可招收博士后及博、硕士研究生，欢迎申请华西医院专职博士后。

研究人员、研究方向简介

     主任：蒋扬富 教授，博士生导师

研究方向：肿瘤细胞与分子生物学、肿瘤分子靶向治疗基础。

代表性论著：

1. Yin YC, Hua H, Li MJ, Liu S, Kong QB, Shao T, Wang J, Luo YM, Wang Q, Luo T, Jiang Y. mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. Cell Research 2016;26:46-65.

2. Hua H, Zhang H, Chen J, Wang J, Liu J, Jiang Y. Targeting Akt in cancer for precision therapy. Journal of Hematology & Oncology 2021; 14:128.

3. Hua H, Kong Q, Yin J, Zhang J, Jiang Y. Insulin-like growth factor receptor signaling in tumorigenesis and drug resistance: a challenge for cancer therapy. Journal of Hematology & Oncology 2020;13:64. 

4. Shao T, Song P, Hua H, Zhang H, Sun X, Kong Q, Wang J, Luo T, Jiang Y. Gamma-synuclein is a novel Twist1 target that promotes TGF-β-induced cancer cell migration and invasion. Cell Death & Disease 2018;9:625.

5. Liu S, Wang J, Shao T, Song P, Kong Q, Hua H, Luo T, Jiang Y. The natural agent rhein induces β-catenin degradation and tumor growth arrest. Journal of Cellular and Molecular Medicine. 2018; 22:589-599. 

6. Huo X, Liu S, Shao T, Hua H, Kong Q, Wang J, Luo T, Jiang Y. GSK3 Protein Positively Regulates Type I Insulin-like Growth Factor Receptor through Forkhead Transcription Factors FOXO1/3/4. Journal of Biological Chemistry 2014;289:24759-24770.

7. Teng Y; Gao M; Wang J; Kong Q; Hua H; Luo T; Jiang Y Inhibition of eIF2α dephosphorylation enhances TRAIL-induced apoptosis in hepatoma cells. Cell Death & Disease 2014;5: e1060.

8. Ma W, Teng Y, Hua H, Hou J, Luo T, Jiang Y. Upregulation of heat shock protein 27 confers resistance to actinomycin D-induced apoptosis in cancer cells. FEBS J 2013; 280:4612–4624.

9. Hua H, Li M, Luo T, Yin Y, Jiang Y. Matrix metalloproteinases in tumorigenesis: an evolving paradigm. Cellular and Molecular Life Sciences 2011;68:3853-3868.

10. Li M, Yin Y, Hua H, Sun X, Luo T, Wang J, Jiang Y. The reciprocal regulation of γ-synuclein and insulin growth factor-I (IGF-I) receptor expression creats a circuit that modulates IGF-I signaling. Journal of Biological Chemistry. 2010; 285:30480-30488.

11. Luo T, Wang J, Yin Y, Hua H, Jing J, Sun X, Li M, Zhang Y, Jiang Y. (-)-Epigallocatechin gallate sensitizes breast cancer cells to paclitaxel in a murine model of breast carcinoma. Breast Cancer Research 2010;12:R8.

12. Wang J, Yin Y, Hua H, Li M, Luo T, Xu L, Wang R, Liu D, Zhang Y, Jiang Y. Blockade of GRP78 sensitizes breast cancer cells tomicrotubules-interfering agents that induce the unfolded protein response. Journal of Cellular and Molecular Medicine 2009;13:3888-3897.

13. Hua H, Xu L, Wang J, Jing J, Luo T， Jiang Y. Up-regulation of gamma-synuclein contributes to cancer cell survival under endoplasmic reticulum stress. Journal of Pathology 2009;217:507–515.

14. Wang J, Hua H, Ran Y, Zhang H, Liu W, Yang Z, Jiang Y. Derlin-1 is overexpressed in human breast carcinoma and protects cancer cells from endoplasmic reticulum stress-induced apoptosis. Breast Cancer Research 2008;10:R7.

     科研技师

姓名：张红颖 博士

研究方向：肿瘤细胞与分子生物学

代表论著：

1. Zhang H, Yang S, Wang J, Jiang Y. Blockade of AMPK-mediated cAMP–PKA–CREB/ATF1 signaling synergizes with aspirin to inhibit  hepatocellular  carcinoma. Cancers (Basel) 2021;13:1738.  

2. Zhang H, Kong Q, Wang J, Jiang Y, Hua H. Complex roles of cAMP–PKA–CREB signaling in cancer. Exp Hematol Oncol 2020;9:32.

三、特色平台/设备（简要）

细胞与分子生物学实验平台

本研究室具备开展肿瘤生物学研究的实验条件。具有细胞培养、核酸及蛋白电泳、梯度PCR仪、紫外分光光度计、冷冻高速离心机、酶标仪、凝胶及化学发光检测系统、倒置荧光显微镜、超低温冰箱、荧光及化学发光分析仪等。

位置：成都市高新区科园4路1号 华西医院科技园5楼

联系方式：028-85164044