1. Recently, Professor Li Fei’s team from Frontiers Science Center for Disease-related Molecular Network published a review titled “Recent advances in metabolism and toxicity of tyrosine kinase inhibitors” in Pharmacology & Therapeutics (IF: 13.4). This comprehensive review systematically summarized ten subclasses of active metabolites of tyrosine kinase inhibitors (TKIs) produced in vivo, and perturbations of fourteen metabolic pathways such as bile acid metabolism, nucleotide metabolism and intestinal flora metabolism that may underlie the toxicity and side effects of TKIs. At the end of this review, potential therapeutic targets for the prevention or treatment of organ damage induced by TKI were highlighted, providing fundamental evidence and scientific basis for the development of strategy to alleviate the toxicity and side effects and improve the safety of the clinical use of TKIs.
https://www.sciencedirect.com/science/article/abs/pii/S0163725822001504?via%3Dihub
2. On Sept. 12, the team led by Professor Chen Chong and Professor Liu Yu from State Key Laboratory of Biotherapy joined hands with the team led by Professor Wei Qiang from Department of Urology published a research paper titled “Acquired semi-squamatization during chemotherapy suggests differentiation as a therapeutic strategy for bladder cancer” in Cancer Cell (IF: 38.585). It has been found that semi-squamous differentiation is a new characteristic of chemotherapy-resistant bladder cancer, and then a differentiation therapy targeting Cathepsin H (CTSH) to promote the terminal differentiation of drug-resistant tumor cells has been proposed, providing a new approach to the differentiation therapy of solid tumors.
https://doi.org/10.1016/j.ccell.2022.08.010
3. Recently, the team led by Professor Jiang Ruotian from National and Local Joint Engineering Research Center for Anesthesia Translational Medicine, and that led by Professor Liu Longqian from Department of Ophthalmology/Optometry, jointly published a research paper titled “Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in health and aging retina online” in Science Advances (IF: 14.972). This research not only for the first time reveals a two-pore domain potassium channel in retina playing a critical role in visual signal integration, but also suggests a potential new strategy for slowing down age-related vision loss.
https://www.science.org/doi/10.1126/sciadv.abn8785
4. Recently, Professor Xu Xuewen’s team from Department of Plastic Surgery/Burn and Professor Li Tao’s team from Laboratory of Mitochondria and Metabolism jointly published a review paper titled “Signaling pathways in obesity: mechanisms and metabolic intervals” in the famous journal Signal Transduction and Targeted Therapy (IF: 38.104) in the field of biochemistry and molecular biology. This review systematically summarized the signaling pathways and molecular mechanisms involved in obesity found in preclinical studies, and outlined the development history, research status and the targets of obesity therapeutic drugs, thus providing a reference for obesity-related mechanism research and targeted therapy.
https://www.nature.com/articles/s41392-022-01149-x
5. Recently, the research team led by Professor Zong Zhiyong from Center of Infectious Diseases discovered a new bacterial genus and named it Huaxiibacter. The discovery was published in August 2022 in the International Journal and Systems of Evolutionary Microbiology, the authoritative international journal for bacterial taxonomy. The type strain of the genus is associated with human infection. The discovery of Huaxiibacter has scientific value for precise identification of bacteria in clinical laboratory, accurate epidemiological investigations, and antimicrobial resistance monitoring.
https://pubmed.ncbi.nlm.nih.gov/35976100/
6. Recently, Professor Qiu Li from Department of Ultrasound Medicine and her medical-engineering interdisciplinary research group published a cover paper titled “Modulating electron transfer in vanadium-based artistic enzymes for enhanced ROS-Catalysis and disinfection” in Advanced Materials (IF: 32.086), a well-known journal in the field of materials and biomedicine. In this article, it revealed a new vanadium-based HPO artificial enzyme material by using a unique Zn-O-V bridge and verified the same antibacterial properties as vancomycin, which can effectively promote neovascularization in wound-healing, reduce inflammatory reactions in the process of tissue repair, and provide new research ideas for designing artificial enzymes.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202108646
